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KMID : 0358219920190020181
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Korean Journal of Fertility and Sterility
1992 Volume.19 No. 2 p.181 ~ p.188
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Clinical Efficacy o fSalmon Calcitonin aainst Bone Pain in Postmenopausal
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이효표
김병기/송용상/김승철/강순범
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Abstract
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Calcitonin exerts a positive effects on bone pain. The relief of bone pain has been well known in Paget's disease and malignancy patients with bone metastasis who were treated with salmon calcitonin. We carried out a clinical study evaluating
efficacy
of salmon calcitonin in reducing bone pain and improving mobility of the postmenopausal osteoporosis women. Fifty women suffering pain from postmenopausal osteoporosis diagnosed by evidence of radiology and/or dual photon absorptiometry were
treated
with salmon calcitonin 50 MRC three times per week for 4 weeks. The severity of pain estimated by visual analogue scale (VAS) was reduced significantly in treated patients from 8.6±0.7 on day 0 to 2.7±1.8 on day 28. The mobility of the patients
was
improved in 2 weeks after salmon calcitonin treatment. Mild adverse effects were seen in 8 (16%) patients; headache in 4 (8%), sweating and dizziness in 2 (4%), pain at the injection site in 1 (2%), nausea and vomiting in 1 (2%) patient. The
treatment
was stopped in 3 patients by their request. Salmon calcitonin was effective in 39 (83%) of 47 patients above moderate degree. In conclusion, salmon calcitonin is useful in the treatment of patients with pain from postmenopausal osteoporosis.
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KEYWORD
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